Macrophage Autophagy and Bacterial Infections
نویسندگان
چکیده
منابع مشابه
Macrophage Autophagy and Bacterial Infections
Autophagy is a well-conserved lysosomal degradation pathway that plays key roles in bacterial infections. One of the most studied is probably xenophagy, the selective capture and degradation of intracellular bacteria by lysosomes. However, the impact of autophagy goes beyond xenophagy and involves intensive cross-talks with other host defense mechanisms. In addition, autophagy machinery can hav...
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Converging studies have shown that M1 and M2 macrophages are functionally polarized in response to microorganisms and host mediators. Gene expression profiling of macrophages reveals that various Gram-negative and Gram-positive bacteria induce the transcriptional activity of a "common host response," which includes genes belonging to the M1 program. However, excessive or prolonged M1 polarizati...
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Background: Microbial infections and the resistance to antibacterial drugs are on the rise, and scientists are in search of the safest and most effective approach to overcome them. Medicinal plants are potentially effective against many microorganisms. Therefore, this study was planned to examine the antibacterial properties and cytotoxicity of the extracts of Allium sativum and Myrtus communis...
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Backgrounds: Neutropenia can be associated with life-threatening infections. Gram negative and staphylococcal infections are the most common pathogens. The spectrum of bacterial isolates has changed considerably over the past four decades. The objective of the present study was to evaluate the pattern of bacterial and fungal infections in neutropenic pediatric patients. Methods: A non-randomize...
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ژورنال
عنوان ژورنال: Frontiers in Immunology
سال: 2017
ISSN: 1664-3224
DOI: 10.3389/fimmu.2017.01483